Items tagged with: skin
Beauty might only be skin deep, but for those wondering how to keep that skin young, Japanese scientists may have found an answer in the form of a protein
Article word count: 455
HN Discussion: https://news.ycombinator.com/item?id=19631496
Posted by clouddrover (karma: 4351)
Post stats: Points: 140 - Comments: 13 - 2019-04-11T05:49:04Z
#HackerNews #japanese #keeps #protein #skin #study #that #uncovers #youthful
Beauty might only be skin deep, but for those wondering how to keep that skin young, Japanese scientists may have found an answer in the form of a protein that encourages cell competition.
The prosaically named COL17A1 might not sound like a fountain of youth, but the new study suggests it does the heavy lifting when it comes to keeping skin intact and unimpaired.
The protein works by encouraging cell competition, a key process to maintain tissue fitness. That effectively “drives out” weaker cells while encouraging replication of stronger ones.
“Damaged or stressed stem cells can be selectively eliminated by intact stem cells every day in our skin,” said research leader Emi Nishimura, a professor at Tokyo Medical and Dental University’s Stem Cell Biology department.
But aging results in a depletion of COL17A1, as do familiar enemies of youthful skin, like UV radiation and other stress factors.
And when that happens, weaker cells replicate, leaving the skin thinner, more prone to damage and slower to heal.
The research, published Thursday in the journal Nature, is based on investigations using mice tails, which share many of the same characteristics as human skin.
After confirming the importance of COL17A1, the team decided to investigate whether they could stimulate the protein once it was depleted — effectively looking for compounds that could kick-start the anti-aging process in skin.
They isolated two chemical compounds — Y27632 and apocynin — and tested both on skin cells, with positive results.
“Application of these drugs to full-thickness skin wounds significantly promoted wound repair,” the study said.
The two compounds point to ways of “facilitating skin regeneration and reducing skin aging,” the study added.
In a review of the study commissioned by Nature, two professors from the University of Colorado said cell competition had previously only been studied extensively in fruit flies.
The research “provides evidence that healthy cells in mammals can also efficiently repopulate adult tissues, replacing unfit or damaged cells,” wrote professors Ganna Bilousova and James DeGregori.
And they said the research offered “proof-of-principle” that the two chemical compounds could combat aging.
“Future studies are needed to determine the mechanisms of cell competition in other tissues, and to identify compounds capable of reversing aging in other organs,” they said.
Nishimura said that the work could eventually lead to products like creams or tablets that could stop skin deterioration and promote repair.
“We are going to collaborate with pharmaceutical or cosmetic companies for the clinical use of the chemicals,” she said.
She said additional research would investigate whether the same process might also be at work in other parts of the body that have so-called epithelial cells like skin does.
“We are working on other epithelial organs as well to find out (whether) similar competition may underlie long-term tissue maintenance as well as organ aging,” she said.
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#girl #beauty #beautiful #fashion #woman #adult #care #female #health #dark #caucasian #healthy #young #tender #skin #brunette #medicine #spot #different #sweet #pale #jacket #disorder #attractive #normal #weak #medical #treatment #problem #patient #disease #condition #ugly #cosmetic #healthcare #heterochromia #forehead #pigment #vitiligo #affected #patchy #dermatology #autoimmune #pigmentation #chronic #lentigo #dermatitis #melanin #melanocytes #depigmentation #AndriiAfanasiev #andreonegin #500px
Home > Volume 3 > Blessed Are Those Who Overcome for My Name’s Sake
11/9/06 From YahuShua HaMashiach, Our Lord and Savior
The #Word of The Lord Spoken to Timothy
For Someone Who Asked if They Can Still Serve The Lord as a #Pastor
Even Though They Are #Homosexual, and For All Those Who Have #Ears to #Hear
Thus says The Lord to His servant, whom He loves: You seek Me, and this is very #good. Yet if you wish to please Me, then you must first become My #disciple, a devoted #servant who walks in My ways.
My son, I have not forsaken you. If you ask of Me #forgiveness, I shall surely #forgive you, even for all you have done. Yet to continue in those same sins, for which you had sought forgiveness, is most unpleasant in My #sight. For by doing so, you have made My forgiveness of no effect. For that which requires forgiveness is the very same from which you must depart, lest your #repentance become unrepentance, crucifying Me again and again in your #heart.
For repentance is more than the asking...
It must come from a deep desire to be set #free
In My #love, followed by a sincere unyielding
#Commitment to make your love perfect
The shedding of the #skin of this #world,
The crucifying of your old man with his sinful ways...
The putting on of the new man who is
Renewed in the #knowledge of The #Holy One,
Conforming to the #image of Him who created him...
Says The Lord.
My son, there is none righteous in all the world, no, not one. All have sinned and fall short of the #Glory of God. Behold, even Timothy, a man who I have given to hear My #voice, does continually stumble. Yet when he is weak, he becomes #strong. For My #grace is sufficient for him, and My #strength is made #perfect in his weakness. For he does not cease from coming to Me, laying himself at My #feet in repentance, taking full responsibility for his actions, remorseful over those things which yet cause him to stumble, being fully tempted as all men. For I have not yet delivered My people out of temptation; nor has the #evil one been bound in the abyss (this time is not yet). Yet from the power of sin, which is death, I have surely delivered you - if you so choose to receive of Me fully, if you so choose to embrace Me as I truly am, if you so choose to remain in My love.
Therefore you know the answer to your question already, for all is written in the Scriptures of #Truth. Shall one, who does that which is an abomination in the #eyes of God, serve Me? He may not. For as it is written: No one who actively engages in or passively practices #homosexuality shall inherit The #Kingdom of God. Behold, even all who voice their agreement shall be left outside the gate, says The Lord. Yet if one comes to Me and asks of Me forgiveness, even a continual washing in My own #blood, he shall surely have it; even if he comes to Me seven times, or seventy times seven times, he shall be forgiven. For I forgive all those who come to Me in sincerity and in truth, and draw near to those of a contrite heart, delivering those of a humble spirit.
Beloved, by this then
Shall our love be made perfect...
You shall abstain from that which is
Not lawful, and make every effort
To depart from that which is an
Abomination in the eyes of God...
You must strive to be completely separate
From that #life, presenting your #body
As a living sacrifice to The Lord...
For that which is unnatural is universally known, though the men and women of this world deny it. And that which is against God shall be purged by #fire. Even all that offends shall be destroyed and come to a swift end. Therefore, My son, take up your #cross and follow Me as I am, and not as you or the churches of men would have Me be. For as it is written: Whoever loves their #mother, #father, #sister, #brother, #child or close friend, more than Me, is not worthy of Me. And he who does not take up his cross and follow after Me is not worthy of Me. For he who holds onto his life in this world will lose it, yet he who gives up his life for My sake will find it.
So then, do I call you to serve Me? I do, if you are willing to serve Me in all righteousness, without compromise. Do I then require that you be perfect? No. For there is none perfect, save The Holy One of #Israel. Rather I require that you strive to be unto Me a servant of pure heart, of pure intention, a disciple who loves Me with all his #heart, understanding and strength, and also loves his #neighbor as himself. For it is written and remains standing, that one can not be crowned unless they strive lawfully.
My son, I am the fulfillment of The #Law, the very #goal at which the #Torah aims. Thus all those who embrace Me are freed from the curse of The Law, but by no means are they now free to forsake The Law. Rather let The Law be written in your heart, for now you are under grace, and by the power of My own #spirit are you now able to keep The Law... Beloved, come to Me and receive! Let Me #wash you and make you clean, that you may now arise and walk in My ways.
Therefore again I say to you, serve Me as I am, and not as you would have Me be. Yet turn away unto strange #flesh, and I shall also turn away from you, leaving you in the midst of the #earth, until you are truly ready to give up your life for My sake. My son, come out from among them and be separate, and I shall give you a cool drink of #water, for you are yet thirsty. Hear My words and understand. For My words are life for those who walk in them. And if you walk in them, then you are really My #disciple, says The Lord.
↑ Romans 3:10
↑ Romans 3:23
↑ 2 Corinthians 12:9
↑ John 15:10
↑ 1 Corinthians 6:9-10 (CJB)
↑ Revelation 22:15
↑ Matthew 18:21-22
↑ Matthew 10:37-39
↑ Mark 12:30-31
↑ 2 Timothy 2:5 (KJV)
↑ Romans 10:4 (CJB)
↑ 1 John 3:24 (NKJV)
↑ Matthew 16:25
↑ 2 Corinthians 6:17
↑ John 8:31 (GNT)
#prophecy #prophet #Jesus #Yeshua #Christ #Messiah #God #church #bible #scripture #christian #christianity #JesusChrist #HolySpirit #Savior #Saviour #Lord
Light Therapy and Photobiomodulation....This month we feature four articles about the ways light,laser light,red light,and photobiomodulation,are being used to support and improve health including treatments for skin care,pain relief,cancer,PTSD,brain health,and more.
#Light #Therapy #Photobiomodulation #light #laser #red health #skin #pain #cancer #PTSD #brain #MEDICINE #SCIENCE #BIOLOGY
This Teen's Sudden 'Schizophrenia' Diagnosis Turned Out to Be... a Skin Infection
Hallucinations, delusions, thoughts of suicide and homicide. All the signs pointed to the 14-year-old patient having rapid onset schizophrenia. But when the usual treatments failed, physicians looked elsewhere and found a very different problem.
The true culprit for the teen's decline in mental health was a pathogen associated with what's known as 'cat scratch disease'. While the patient is now doing well, the case has left researchers curious about links between infection and neurological illness...
Melatonin and General Aging Melatonin, a hormone primarily secreted by the pineal gland in the brain, is also produced in skin and hair cells. Melatonin is more than just the “sleep hormone” -- it…
Article word count: 1243
HN Discussion: https://news.ycombinator.com/item?id=19355597
Posted by apsec112 (karma: 15452)
Post stats: Points: 224 - Comments: 78 - 2019-03-10T23:59:40Z
#HackerNews #and #effect #hair #melatonins #skin
Melatonin and General Aging
Melatonin, a hormone primarily secreted by the pineal gland in the brain, is also produced in skin and hair cells. Melatonin is more than just the “sleep hormone” -- it regulates the circadian rhythm, which affects many metabolic and endocrine processes.
Melatonin, and the circadian rhythm more generally, plays a role in staving off aging. Melatonin levels decline as we age, and correspondingly circadian rhythms become less regular. Mice with mutations damaging their circadian rhythm have accelerated-aging syndromes, with obesity, diabetes, muscle loss, and shortened lifespans. Supplementing melatonin in rodents (or administering extracts from the pineal gland, or grafts from fetal pineal glands) has been found to extend lifespan, prolong fertility, reduce cancer incidence, reduce obesity and insulin resistance, and improve neurological recovery from brain injury. Melatonin and compounds that act along the same pathway have potential as aging-preventative drugs.
Melatonin administration also improves skin resistance to damage (such as from UV rays) and increases hair growth.
Melatonin and Skin
In both in-vitro skin culture experiments and human studies, administering melatonin prior to exposure to UV radiation increases cell survival and reduces oxidative damage. Topical melatonin applied to skin 15 minutes prior to exposure to UV radiation completely prevented skin redness (erythema) in a small randomized double-blind study of human subjects.
Melatonin and Hair: Animal and Human Studies
Melatonin also affects hair growth, as the hair growth cycle in mammals is under circadian control. As with other circadian cycles, the hair growth cycle becomes dysregulated and lower in amplitude with age. Mice whose circadian rhythms are damaged (via removal of the pineal gland or knockout of a circadian clock gene) show impaired hair growth as part of an accelerated aging syndrome. When pinealectomized rats are given injections of melatonin, their hair growth recovers to that of healthy rats. Melatonin administration has been found to increase hair growth in a variety of mammals: weasels, ewes , dogs, minks, goats, rabbits, raccoon dogs, and foxes , administered either orally or via subcutaneous implants. There’s a good evolutionary rationale for this effect: melatonin is the hormone that signals the onset of darkness, which triggers many mammals to grow thick winter coats as days grow shorter. In animals which grow white coats in winter and brown coats in summer, experimenters can trigger the growth of the white winter coat by administering melatonin.
There’s even evidence that topical melatonin can reverse hair loss in humans. In a randomized double-blind study of 40 women with hair loss, melatonin solution applied to the scalp increased hair growth significantly relative to placebo. In an open-label, uncontrolled study of topical melatonin involving 1891 male and female patients with androgenic alopecia, at 3 months 61% of patients had no hair loss, compared to 12.2% at the start; 22% had new hair growth at 3 months compared to 4% at baseline. The incidence of seborrheic dermatitis also declined, from 34.5% at baseline to 9.9% at 3 months.
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"Baba Ichanga" wearing traditional gelede mask and holding a baby, evoking the ancestors, his generation and the most recent one. Sanga village.
some great #photos from Benin: Ketou by David Paul Carr... maybe of interest for our beloved @Caroline Erre and other #Africa #dark #skin fans.
He also has a folder named France: A Temporary Autonomous Zone
#mask #Benin #France #photography #DPCarr
7/10/05 From The #Lord, Our #God and #Savior
The #Word of The Lord Spoken to Timothy
For All Those Who Have Ears to Hear
Thus says The Lord: Be wary of all these #men in #authority who dwell in the #churches of men, be wary and vigilant. For they hold tightly to singleness of #doctrine, teaching always that which is built upon the corrupt #knowledge and #understanding of men, men who refuse to let go of that which was passed down to them by their forefathers, by which they also remain #blind. Therefore do not #judge according to #human standards, nor by that which is put forth by men as doctrine, for they are greatly misled. Rather #study to show yourself #approved unto God, a workman that need not be ashamed, rightly dividing the Word of #Truth. For #discernment with #fear is #righteousness.
Beloved ones, embrace the #wisdom and #knowledge of God, break free from all these corrupt doctrines and filthy #traditions held in such high regard. For I ask you, if you dispense the #food of God to the #hungry, while using your own #salt to salt that which has salt in itself, will not the food you offer lose its #flavor and become bitter in the mouths of those who came looking to be fed?
I tell you the #truth, many will there be in My Kingdom who received no #baptism by water. Rather they had been fully immersed in The Word of God, enveloped in The Son’s sacrifice and #love, #baptized in the Spirit of Truth. For most assuredly, I say to you, they have their reward. Therefore, do not cast stumbling #blocks before the #feet of those who love Me. Be one in #Messiah, according to that which dwells inwardly in the #heart. For true #fellowship comes not by #words spoken amongst a #group of #united #people, nor by immersion in #water. Rather it starts with the heart, and is found in the stillness of My #spirit, where My #peace mends the broken and My gentle caress gladdens the heart. For all those found at the feet of The Lord are covered with #grace, and those who abide in My love are indeed of one accord.
Beloved, where in The #Commandments have I written all must be baptized by men to be #saved? Baptism is indeed #good, if it is a #confession poured out from one’s heart in #pure #belief, an outward act of faith revealing one’s #acceptance of their #forgiveness in The Messiah. For the #water of the #earth can only cleanse that which is soiled on the #skin. By no means can it cleanse that which is soiled in the spirit; this is #reserved for the #blood of The #Lamb. Again I say to you, baptism by water is nothing, unless one is first washed by The Word, being baptized in the Spirit of Grace and Truth which is received in #YahuShua #HaMashiach, whom you call #Jesus and #Christ. For HE is The True Baptism, The Very Water of Life, in which all must be cleansed to receive everlasting #life.
Therefore beloved, remember:
The spirit of the Word, and not the #letter,
Is the #way, the #truth and the #life...
For The Messiah is indeed coming quickly,
To baptize all in #fire and #glory...
Those of a #wicked #heart, in fire...
And those of the Spirit, in glory, forever and ever!
↑ John 8:15
↑ 2 Timothy 2:15 (KJV)
↑ Revelation 22:7, Revelation 22:20
#prophecy #prophet #Jesus #Yeshua #Christ #Messiah #God #church #bible #scripture #christian #christianity #JesusChrist #HolySpirit #Savior #Saviour #Lord