Items tagged with: dogma
... Maybe we ought to all just forget this whole idea of requiring priests to be celibate.
Quite a few Christian sects have done so already, and many non-Christian religions never did require it. And you know what? It doesn't seem to have brought about any divine apocalypse.
Trying to enforce the dogma, though ... it's pretty clear THAT'S been causing a major problem.
Perhaps it's time to stop? Perhaps it's LONG PAST time.
#dogma #religion #celibacy
Exercise physiologists agree: muscle memory is real. But how are these 'memories' stored? A review has a simple answer: nuclei gained during training persist even when muscle cells shrink due to…
Article word count: 732
HN Discussion: https://news.ycombinator.com/item?id=19187508
Posted by prostoalex (karma: 72882)
Post stats: Points: 98 - Comments: 57 - 2019-02-17T23:14:17Z
#HackerNews #discovery #dogma #ends #lose #memory #muscle #use
The old adage "use it or lose it" tells us: if you stop using your muscles, theyʼll shrink. Until recently, scientists thought this meant that nuclei -- the cell control centers that build and maintain muscle fibers -- are also lost to sloth.
But according to a review published in Frontiers in Physiology, modern lab techniques now allow us to see that nuclei gained during training persist even when muscle cells shrink due to disuse or start to break down. These residual ʼmyonucleiʼ allow more and faster growth when muscles are retrained -- suggesting that we can "bank" muscle growth potential in our teens to prevent frailty in old age. It also suggests that athletes who cheat and grow their muscles with steroids may go undetected.
Our biggest cells are in our muscles, and theyʼre all fused together
Syncytium. Sounds like a neo-noir comic book series. Itʼs actually a special type of tissue in your body, where cells are fused together extra close -- so close, that they behave a like a giant single cell.
"Heart, bone and even placenta are built on these networks of cells," says Lawrence Schwartz, Professor of Biology at the University of Massachusetts. "But by far our biggest cells -- and biggest syncytia -- are our muscles." Like the Sin City series, it appeared at first that everything was black and white with syncytia.
"Muscle growth is accompanied by the addition of new nuclei from stem cells to help meet the enhanced synthetic demands of larger muscle cells," explains Schwartz. "This led to the assumption that a given nucleus controls a defined volume of cytoplasm -- so that when a muscle shrinks or ʼatrophiesʼ due to disuse or disease, the number of myonuclei decreases."
A muscle can gain nuclei, but never loses them
This assumption long seemed valid, with many researchers reporting the presence of disintegrating nuclei in muscle tissue during atrophy induced by inactivity, injury or paralysis. But modern cell-type-specific dyes and genetic markers have shown that the dying nuclei other researchers had detected were in fact inflammatory and other cells recruited to atrophic muscle.
The new evidence paints a very different picture of muscle syncytium.
"Two independent studies -- one in rodents and the other in insects -- have demonstrated that nuclei are not lost from atrophying muscle fibers, and even remain after muscle death has been initiated."
This suggest that once a nucleus has been acquired by a muscle fiber, it belongs to the muscle syncytium -- probably for life. But Schwartz, for one, is unsurprised by the new findings.
"Muscles get damaged during extreme exercise, and often have to weather changes in food availability and other environmental factors that lead to atrophy. They wouldnʼt last very long giving up their nuclei in response to every one of these insults."
"Use it or lose it -- until you use it again"
Since myonuclei are the synthetic engine of muscle fibers, retaining them should enable muscle size and strength to recover more quickly after one of these insults, and help to explain the phenomenon of ʼmuscle memoryʼ.
"It is well documented in the field of exercise physiology that it is far easier to reacquire a certain level of muscle fitness through exercise than it was to achieve it the first place, even if there has been a long intervening period of detraining. In other word, the phrase "use it or lose it" is might be more accurately articulated as ʼuse it or lose it, until you work at it againʼ."
As such, the findings have important implications beyond understanding muscle biology.
"Informing public health policy, the discovery that myonuclei are retained indefinitely emphasizes the importance of exercise in early life. During adolescence muscle growth is enhanced by hormones, nutrition and a robust pool of stem cells, making it an ideal period for individuals to "bank" myonuclei that could be drawn upon to remain active in old age."
The findings also support frequent drugs testing for competitive athletes, with permanent bans for proven steroid cheats since they will benefit from the steroids long after their use has ended.
"Anabolic steroids produce a permanent increase in usersʼ capacity for muscle development. In keeping with this, studies show that mice given testosterone acquire new myonuclei that persist long after the steroid use ends."
Materials provided by Frontiers. Note: Content may be edited for style and length.
HackerNewsBot debug: Calculated post rank: 84 - Loop: 158 - Rank min: 80 - Author rank: 77
why peer review in scientific method is a sham
The mistake, of course, is to have thought that #peer-review was any more than a crude means of discovering the acceptability — not the validity — of a new finding…We portray peer review to the public as a quasi-sacred process that helps to make #science our most #objective #truth teller. But we know that the system of peer review is #biased, #unjust, #unaccountable, incomplete, easily fixed, often insulting, usually ignorant, occasionally foolish, and frequently wrong.#scientificMethod
Certain sorts of #innovation are welcome in science, when they fall within established frameworks and do not threaten vested interests. But aside from this sort of routine innovation, science has many similarities to systems of #dogma. #Dissenters are not welcome. They are ignored, rejected, and sometimes attacked.